Does Location of Epicardial Adipose Tissue Correspond to Endocardial High Dominant Frequency or Complex Fractionated Atrial Electrogram Sites During Atrial Fibrillation?

• DOI: 10.1161/circep.112.971200
• Publication Date: 2012-07-08T01:31:20Z
• Authors: Koichi Nagashima; Yasuo Okumura; Ichiro Watanabe; Toshiko Nakai; Kimie Ohkubo; Masayoshi Kofune; Hiroaki Mano; Kazumasa Sonoda; Takafumi Hiro; Mizuki Nikaido; Atsushi Hirayama
• Keywords: Epicardial adipose tissue

Although increased epicardial adipose tissue (EAT) volume is known to be associated with prevalence of atrial fibrillation (AF), the exact mechanisms are unclear. Therefore, we investigated whether EAT locations were high dominant frequency (DF) sites or complicated fractionated electrogram during AF.Three-dimensional reconstruction computed tomography images depicting volumes (obtained by 320-detector-row multislice tomography) merged NavX-based DF and maps obtained AF for 16 patients paroxysmal 18 persistent AF. Agreement between EAT, especially surrounding left atrium, was quantified. In addition, serum biomarker levels determined. atrium significantly greater in than (52.9 cm(3) [95% CI, 44.2-61.5] versus 34.8 26.6-43.0]; P=0.007). Serum high-sensitivity C-reactive protein interleukin-6 higher (median protein, 969 ng/mL [interquartile range, 307-1678] 320 120-660]; P=0.008; median interleukin-6, 2.4 pg/mL 1.7-3.2] 1.3 0.8-2.4] pg/mL; P=0.017). excellent agreement (κ=0.77 0.71-0.82]) but poor (κ=0.22 0.13-0.31]).Increased elevation inflammatory biomarkers noted rather patients. High located adjacent sites. Thus, may involved maintenance