Intermittent Fasting After ST-Segment–Elevation Myocardial Infarction Improves Left Ventricular Function: The Randomized Controlled INTERFAST-MI Trial

• DOI: 10.1161/circheartfailure.123.010936
• Publication Date: 2024-05-02T09:00:38Z
• Authors: Jochen Dutzmann; Zoe Kefalianakis; Florian Kahles; Jan-Marcus Daniel; Hubert Gufler; Walter Alexander ...; Kai Knöpp; Daniel G. Sedding
• Keywords: Interquartile range; Intermittent Fasting

BACKGROUND: Intermittent fasting has shown positive effects on numerous cardiovascular risk factors. The INTERFAST-MI trial (Intermittent Fasting in Myocardial Infarction) been designed to study the of intermittent cardiac function after STEM (ST-segment–elevation myocardial infarction) and feasibility future multicenter trials. METHODS: was a prospective, randomized, controlled, nonblinded, single-center investigator-initiated trial. From October 1, 2020, July 15, 2022, 48 patients were randomized groups or regular diet followed for 6 months with follow-up visits at 4 weeks 3 months. RESULTS: In all, 22 24 group mean age 58.54±12.29 years 20 59.60±13.11 included intention-to-treat population. primary efficacy end point (improvement left ventricular ejection fraction weeks) significantly greater compared control (mean±SD, 6.636±7.122%. versus 1.450±4.828%; P =0.038). This effect still significant even more pronounced showed reduction diastolic blood pressure body weight group. adherence median 83.7% (interquartile range, 69.0%–98.4%) all days. None from either reported dizziness, syncope, collapse. CONCLUSIONS: Our results suggest that infarction may be safe could improve STEMI. REGISTRATION: URL: https://www.drks.de ; Unique identifier: DRKS00021784.