Age- and Gender-Specific Changes in the Left Ventricular Relaxation

• DOI: 10.1161/circimaging.108.809087
• Publication Date: 2009-01-20T23:28:34Z
• Authors: Hiroyuki Okura; Yuko Takada; Azusa Yamabe; Tomoichiro Kubo; Koichiro Asawa; Takeshi Ozaki; Hiroyuki Yamagishi; Iku Toda; Minoru Yoshiyama; Junichi Yoshikawa; Kiyoshi Yoshida
• Keywords: Quartile

Although left ventricular diastolic function has been shown to deteriorate with advancing age, its gender-specific change is unknown. The aim of this study was investigate age- and changes in tissue Doppler-derived index, E'.A total 1333 healthy individual without known heart disease or hypertension (mean 55 years; range, 10 89) were enrolled studied. Peak early mitral annular velocity (E') peak late (A') recorded measured. As an index the relaxation, E' used. filling pressure, E/E' calculated. systolic indices poorly correlated well age. Among those aged 30 39 40 49 years, significantly lower males than females. In subjects 50 59 60 69 similar both genders. 70 79 80 89 females males. Predictors lowest quartile among >50 years age (P<0.0001; chi(2)=66.11; odds ratio, 1.08; 95% CI, 1.058 1.097) female gender (P=0.002; chi(2)=9.23; 1.68; 1.202 2.343).Age-related specific. elderly population, deteriorated more male gender. These results may explain relatively higher incidence patients failure cardiovascular mortality