Prognostic Value of Routine Cardiac Magnetic Resonance Assessment of Left Ventricular Ejection Fraction and Myocardial Damage

• DOI: 10.1161/circimaging.111.964965
• Publication Date: 2011-09-13T06:46:01Z
• Authors: Igor Klem; Dipan J. Shah; Richard D. White; Dudley J. Pennell; Albert C. van Rossum; Matthias Regenfus; Udo Sechtem; Paulo R. Schvartzman; Peter Hunold; Pierre Croisille; Michele Parker; Robert M. Judd; Raymond J. Kim
• Keywords: Interquartile range; Cardiac magnetic resonance

Background— Cardiac magnetic resonance (CMR) is considered the reference standard for assessment of left ventricular ejection fraction (LVEF) and myocardial damage. However, few studies have evaluated relationship between CMR findings patient outcome, these, most are small none multicenter. We performed an international, multicenter study to assess prognostic importance routine in patients with known or suspected heart disease. Methods Results— From 10 centers 6 countries, consecutive undergoing LVEF damage by cine delayed-enhancement imaging (DE-CMR), respectively, were screened enrollment. Clinical data, protocol information, collected at all sites submitted data coordinating center verification completeness analysis. The primary end point was all-cause mortality. A total 1560 (age, 59±14 years; 70% men) enrolled. Mean 45±18%, 1049 (67%) had hyperenhanced tissue (HE) on DE-CMR indicative During a median follow-up time 2.4 years (interquartile range, 1.2, 2.9 years), 176 (11.3%) died. Patients who died more likely be older ( P <0.0001), coronary disease =0.004), lower segments HE <0.0001). In multivariable analysis, age, LVEF, number independent predictors Among near-normal (≥50%), those above-median (>4 segments) reduced survival compared below- at-median =0.02). Conclusions— Both amount as assessed Even significant identifies cohort high risk early