Drug-Eluting Stents in Bifurcations

• DOI: 10.1161/circinterventions.108.846089
• Publication Date: 2010-03-03T03:19:30Z
• Authors: Patrice Guérin; Paul Pilet; Gérard Finet; Yann Gouëffic; Jean Michel N'Guyen; Dominique Crochet; Isabelle Tijou; Pierre Pacaud; Gervaise Loirand
• Keywords: Ostium

Background— The use of a drug-eluting stent (DES) has strongly limited the incidence in-stent restenosis in bifurcation lesions; nevertheless, still remains problem at origin side branch. aim this study is to analyze consequences kissing postdilatation technique on 5 DESs, using microfocus x-ray computerized tomography and scanning electron microscopy. Methods Results— Five different DESs (Cypher, Cypher Select, Endeavor, Taxus Express, Liberté) were deployed protocols bench-top model. For all types DES, analysis showed that (1) by 2 coaxial balloons caused elliptic deformation proximal segment (2) reduced ratio potential metal artery (manufacturer’s data/calculated [%]: Cypher, 12.7/8.8; 13.5/10.2; 19.0/13.3; 20.5/4.7; Liberté, 17.9/12.5) drug application area segment, including ostial struts (struts adjacent lying around branch ostium) [μg/mm ]: 1.4/1.0; 1.4/1.1; 1.6/1.1; 1.0/0.7; 1.0/0.7). Scanning microscopy significantly greater coating damage stents evaluated ( P <0.05). Conclusions— Commercially available subjected simultaneous balloon an unconstrained model may contribute polymer coating.