Prognostic Implications of Pulmonary Hypertension in Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Implantation

• DOI: 10.1161/circinterventions.113.000482
• Publication Date: 2014-02-26T06:15:51Z
• Authors: Adrien Luçon; Emmanuel Oger; Marc Bedossa; Dominique Boulmier; Jean Philippe Ver...; Hélène Eltchaninoff; Bernard Iung; Alain Leguerrier; Marc Laskar; Pascal Leprince; Martine Gilard; Hervé Le Breton
• Keywords: Aged, 80 and over; Heart Valve Prosthesis Implantation; Male; Cardiac Catheterization; Hypertension, Pulmonary; Aortic Valve Stenosis; Kaplan-Meier Estimate; Prognosis; Severity of Illness Index; 3. Good health; Survival Rate; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Echocardiography; Risk Factors; Aortic Valve; Humans; Female; Registries; Aged; Follow-Up Studies; Retrospective Studies

Background— Pulmonary hypertension (PH) is associated with poor prognosis in patients severe aortic stenosis. The aim of this multicenter study was to describe clinical outcome after transcatheter valve implantation. Methods and Results— FRANCE 2 Registry included all undergoing implantation France 2010 2011. Patients were divided into 3 groups depending on systolic pulmonary artery pressure (sPAP) estimated transthoracic echocardiography: group I, sPAP <40 mm Hg (no PH); II, 40 59 (mild-to-moderate III, ≥60 (severe PH). followed up for 1 year. A total 2435 whose pre–transcatheter reported included. 845 I (34.7%), 1112 II (45.7%), 478 III (19.6%). Procedural success, early complications, 30-day mortality statistically similar across groups. One-year higher (group 22%; 28%; P =0.032). Mild-to-moderate PH identified as an independent factor all-cause mortality. major adverse cardiovascular event rates did not differ according sPAP. New York Health Association functional class improved significantly Conclusions— (sPAP ≥40 Hg) stenosis increased 1-year especially when but mortality, status regardless PAP level.