Long-Term Changes in Invasive Physiological Pressure Indices of Stenosis Severity Following Transcatheter Aortic Valve Implantation

• DOI: 10.1161/circinterventions.121.011331
• Publication Date: 2021-11-23T10:00:44Z
• Authors: Muhammad Sabbah; Francis R. Joshi; Mikko Minkkinen; Lene Holmvang; Hans-Henrik Tilsted; Frants Pedersen; Kiril Ahtarovski; Rikke Sørensen; Niels Thue Olsen; Lars Søndergaard; Ole De Backer; Thomas Engstrøm; Jacob Lønborg
• Keywords: Fractional Flow Reserve; Aortic pressure

Patients with severe aortic stenosis frequently have coexisting coronary artery disease. Invasive hyperemic and nonhyperemic pressure indices are used to assess disease severity but not been evaluated in the context of stenosis.We compared lesion reclassification rates fractional flow reserve (FFR) resting full-cycle ratio (RFR) measured before 6 months after transcatheter valve implantation using conventional clinical cutoffs ≤0.80 for FFR ≤0.89 RFR. This was a substudy ongoing NOTION-3 trial (Third Nordic Aortic Valve Intervention). Two-dimensional quantitative analysis changes angiographic severity.Forty patients were included contributing 50 lesions which measured. In 32 (36 lesions), RFR also There no significant change diameter from baseline follow-up, 49.8% (42.9%-57.1%) versus 52.3% (43.2%-57.8%), P=0.50. improved significantly 0.88 (0.83%-0.93) at 0.92 (0.83-0.95) P=0.003, whereas remained unchanged, 0.84 (0.81-0.89) 0.86 (0.78-0.90), P=0.72. At baseline, 11 out (22%) FFR-positive, 15 (30%) positive P=0.219. Corresponding numbers 23 36 (64%) 12 (33%) P=0.003.In stenosis, physiological assessment leads lower rate 6-month