Genetic Manipulation of Periostin Expression Reveals a Role in Cardiac Hypertrophy and Ventricular Remodeling

• DOI: 10.1161/circresaha.107.149047
• Publication Date: 2007-06-15T01:14:18Z
• Authors: Toru Oka; Jian Xu; Robert A. Kaiser; Jaime Melendez; Michael Hambleton; Michelle A. Sargent; Angela Lorts; Eric W. Brunskill; Gerald W. Dorn; Simon J. Conway; Bruce J. Aronow; Jeffrey Robbins; Jeffery D. Molkentin
• Keywords: Periostin; Ventricular remodeling; Tissue Remodeling

The cardiac extracellular matrix is a dynamic structural support network that both influenced by, and regulator of, pathological remodeling hypertrophic growth. In response to pathologic insults, the adult heart reexpresses secreted protein periostin (Pn). Here we show Pn critically involved in regulating response, interstitial fibrosis, ventricular following long-term pressure overload stimulation myocardial infarction. Mice lacking gene encoding ( Postn ) were more prone rupture first 10 days after infarction, but surviving mice showed less fibrosis better performance. −/− also hypertrophy overload, suggesting an intimate relationship between regulation of remodeling. contrast, inducible overexpression protected from infarction induced spontaneous with aging. With respect mechanism underlying these alterations, hearts altered molecular program fibroblast function. Indeed, fibroblasts isolated effective adherence myocytes characterized by dramatic alteration global expression (7% all genes). These are genetic data detailing function as hypertrophy.