Endothelial Arginase II

• DOI: 10.1161/circresaha.107.169573
• Publication Date: 2008-02-29T02:40:23Z
• Authors: Sungwoo Ryoo; Gaurav Gupta; Alexandre Benjo; Hyun Kyo Lim; Andre Camara; Gautam Sikka; Hyun Kyung Lim; Jayson Sohi; Lakshmi Santhanam; Kevin Soucy; Eric Tuday; Ezra Baraban; Monica Ilies; Gary Gerstenblith; Daniel Nyhan; Artin Shoukas; David W. Christia...; Nicholas J. Alp; Hunter C. Champion; David Huso; Dan E. Berkowitz
• Keywords: Endothelial Dysfunction; Apolipoprotein E

Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease endothelial NO in human aortic cells. Here, we demonstrate that vascular is increased atherogenic-prone apolipoprotein E–null (ApoE −/− ) wild-type mice fed a high cholesterol diet. In ApoE mice, selective II inhibition or deletion of the gene (Arg mice) prevents high-cholesterol diet–dependent decreases production, reactive oxygen species restores function, oxidized lipoprotein–dependent increases stiffness. Furthermore, significantly plaque burden. These data indicate plays critical role pathophysiology cholesterol-mediated dysfunction represents novel target for therapy atherosclerosis.