Insulin-Like Growth Factor-1 Receptor Identifies a Pool of Human Cardiac Stem Cells With Superior Therapeutic Potential for Myocardial Regeneration

• DOI: 10.1161/circresaha.111.240648
• Publication Date: 2011-05-06T04:25:47Z
• Authors: Domenico D'Amario; Mauricio C. Cabra...; Hanqiao Zheng; Claudia Fiorini; Polina Goichberg; Elisabeth Steadman; João Ferreira-Mar...; Fumihiro Sanada; Marco Piccoli; Donato Cappetta; David A. D'Alessa...; Robert E. Michler; Toru Hosoda; Luigi Anastasia; Marcello Rota; Annarosa Leri; Piero Anversa; Jan Kajstura
• Keywords: Male; 0301 basic medicine; 570; Angiotensin II; Myocardium; Stem Cells; Myocardial Infarction; 610; Cell Differentiation; angiotensin II; cell death; cell proliferation; cell senescence; insulin-like growth factor I; insulin-like growth factor II; Coronary Artery Disease; Transplantation, Autologous; Receptor, IGF Type 2; Receptor, IGF Type 1; 3. Good health; 03 medical and health sciences; Insulin-Like Growth Factor II; stem cells; cardiac; heart; regeneration; Humans; Regeneration; Female; Myocytes, Cardiac; Insulin-Like Growth Factor I; Stem Cell Transplantation

Age and coronary artery disease may negatively affect the function of human cardiac stem cells (hCSCs) their potential therapeutic efficacy for autologous cell transplantation in failing heart.