Postnatal Cardiac Gene Editing Using CRISPR/Cas9 With AAV9-Mediated Delivery of Short Guide RNAs Results in Mosaic Gene Disruption

Guide RNA
DOI: 10.1161/circresaha.116.310370 Publication Date: 2017-08-30T00:50:16Z
ABSTRACT
CRISPR/Cas9 (clustered regularly interspaced palindromic repeats/CRISPR-associated protein 9)-based DNA editing has rapidly evolved as an attractive tool to modify the genome. Although been extensively used manipulate germline in zygotes, its application postnatal gene remains incompletely characterized.
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