Epsin Nanotherapy Regulates Cholesterol Transport to Fortify Atheroma Regression

• DOI: 10.1161/circresaha.122.321723
• Publication Date: 2022-11-29T10:00:21Z
• Authors: Kui Cui; Xinlei Gao; Beibei Wang; Hao Wu; Kulandaisamy Arul...; Yunzhou Dong; Yuling Xiao; Xingya Jiang; Marina V. Malovichko; Kathryn Li; Qianman Peng; Yao Wei Lu; Bo Zhu; Rongbin Zheng; Scott Wong; Douglas B. Cowan; MacRae Linton; Sanjay Srivastava; Jinjun Shi; Kaifu Chen; Hong Chen
• Keywords: Foam cell; CD36; ABCG1; Pinocytosis

Excess cholesterol accumulation in lesional macrophages elicits complex responses atherosclerosis. Epsins, a family of endocytic adaptors, fuel the progression atherosclerosis; however, underlying mechanism and therapeutic potential targeting Epsins remains unknown. In this study, we determined role macrophage-mediated metabolic regulation. We then developed an innovative method to therapeutically target macrophage with specially designed S2P-conjugated lipid nanoparticles, which encapsulate small-interfering RNAs suppress Epsins.