Relation Between Red Blood Cell Distribution Width and Cardiovascular Event Rate in People With Coronary Disease

• DOI: 10.1161/circulationaha.107.727545
• Publication Date: 2008-01-03T01:59:14Z
• Authors: Marcello Tonelli; Frank Sacks; Malcolm Arnold; Lemuel Moye; Barry Davis; Marc Pfeffer
• Keywords: Quartile

BACKGROUND: Higher levels of red blood cell distribution width (RDW) may be associated with adverse outcomes in patients heart failure. We examined the association between RDW and risk all-cause mortality cardiovascular a population people coronary disease who were free failure at baseline. METHODS AND RESULTS: performed post hoc analysis data from Cholesterol Recurrent Events study. Baseline was measured 4111 participants randomized to receive pravastatin 40 mg daily or placebo followed for median 59.7 months. used Cox proportional hazards models examine clinical outcomes. During nearly 60 months follow-up, 376 died. A significant noted baseline level adjusted (hazard ratio per percent increase RDW, 1.14; 95% confidence interval, 1.05 1.24). After categorization based on quartile further adjustment hematocrit other factors, graded independent relation death observed (P trend=0.001). For instance, highest had an hazard 1.78 (95% 1.28 2.47) compared those lowest quartile. also increased death/nonfatal myocardial infarction, new symptomatic failure, stroke. CONCLUSIONS: found higher events prior infarction but no