Preoperative Brain Injury in Transposition of the Great Arteries Is Associated With Oxygenation and Time to Surgery, Not Balloon Atrial Septostomy

• DOI: 10.1161/circulationaha.107.760819
• Publication Date: 2009-01-27T01:54:09Z
• Authors: Christopher J. Petit; Jonathan J. Rome; Gil Wernovsky; Stefanie E. Mason; David M. Shera; Susan C. Nicolson; Lisa M. Montenegro; Sarah Tabbutt; Robert A. Zimmerman; Daniel J. Licht
• Keywords: Periventricular leukomalacia

Background— Preoperative brain injury is an increasingly recognized phenomenon in neonates with complex congenital heart disease. Recently, reports have been published that associate preoperative transposition of the great arteries performance balloon atrial septostomy (BAS), a procedure improves systemic oxygenation preoperatively. It unclear whether BAS cause or confounder, because who require are typically more hypoxemic. We sought to determine relationship between and BAS. hypothesized results from hypoxic injury, not itself. Methods Results— Infants (n=26) were retrospectively included larger cohort infants disease underwent MRI as part 2 separate prospective studies. Data collected all pulse oximetry recordings, values arterial blood gas measurements, data. scans performed on day surgery, before surgical repair. Of 26 neonates, 14 No stroke was seen entire cohort, whereas 10 (38%) patients found form periventricular leukomalacia. Periventricular leukomalacia associated BAS; however, had lower ( P =0.026) longer time surgery =0.028) than those without Conclusions— hypoxemia surgery. no association injury.