Triggers of Hospitalization for Venous Thromboembolism

• DOI: 10.1161/circulationaha.111.084467
• Publication Date: 2012-04-04T05:45:30Z
• Authors: Mary A.M. Rogers; Deborah A. Levine; Neil Blumberg; Scott A. Flanders; Vineet Chopra; Kenneth M. Langa
• Keywords: Rate ratio

Background— The rate of hospitalization for venous thromboembolism (VTE) is increasing in the United States. Although predictors hospital-acquired VTE are well-known, triggers before not as clearly defined. objective this study was to evaluate VTE. Methods and Results— A case-crossover conducted. Subjects were participants Health Retirement Study, a nationally representative sample older Americans. Data linked Medicare files hospital nursing home stays, emergency department visits, outpatient visits including physician health from years 1991 2007 (n=16 781). outcome (n=399). Exposures during 90-day period compared with exposures occurring 4 comparison periods. Infection most common trigger VTE, 52.4% risk periods hospitalization. adjusted incidence ratios (IRRs; 95% confidence interval) 2.90 (2.13, 3.94) all infection, 2.63 (1.90, 3.63) infection without previous or skilled facility stay, 6.92 (4.46, 10.72) stay. Erythropoiesis-stimulating agents blood transfusion also associated (IRR=9.33, interval: 1.19, 73.42; IRR=2.57, 1.17, 5.64; respectively). Other included major surgeries, fractures (IRR=2.81), immobility (IRR=4.23), chemotherapy (IRR=5.70). These predictors, combined, accounted large proportion (69.7%) opposed 35.3% Conclusions— Risk prediction algorithms should be reevaluated include erythropoiesis-stimulating agents, transfusion.