Right Ventricular Systolic Function in Organic Mitral Regurgitation

• DOI: 10.1161/circulationaha.112.000999
• Publication Date: 2013-03-14T05:24:36Z
• Authors: Thierry Le Tourneau; Guillaume Deswarte; Nicolas Lamblin; Claude Foucher-Ho...; Georges Fayad; Marjorie Richardson; Anne-Sophie Polge; Claire Vannesson; Yan Topilsky; Francis Juthier; Jean-Noel Trochu; Maurice Enriquez-...; Christophe Bauters
• Keywords: Radionuclide angiography

To assess the prevalence, determinants, and prognosis value of right ventricular (RV) ejection fraction (EF) impairment in organic mitral regurgitation.Two hundred eight patients (62±12 years, 138 males) with chronic regurgitation referred to surgery underwent an echocardiography biventricular radionuclide angiography regional function assessment. Mean RV EF was 40.4±10.2%, ranging from 10% 65%. severely impaired (≤35%) 63 (30%), (left EF<60% EF≤35%) found 34 (16%). Pathophysiologic correlates were left septal (β=0.42, P<0.0001), end-diastolic diameter index (β=-0.22, P=0.002), pulmonary artery systolic pressure (β=-0.14, P=0.047). Mitral effective regurgitant orifice size (n=84) influenced (β=-0.28, P=0.012). In 68 examined after surgery, increased strongly (27.5±4.3-37.9±7.3, P<0.0001) depressed EF, whereas it did not change others (P=0.91). ≤35% 10-year cardiovascular survival (71.6±8.4% versus 89.8±3.7%, P=0.037). Biventricular dramatically reduced (51.9±15.3% 90.3±3.2%, P<0.0001; hazard ratio, 5.2; even adjustment for known predictors (hazard 4.6; P=0.004). also overall (34.8±13.0% 72.6±4.5%, P=0.003; 2.5; P=0.005) (P=0.048).In is frequent (30%) depends weakly on but mainly remodeling function. a predictor postoperative survival, powerful both survival.