Physical Activity and Inflammatory Markers Over 10 Years

• DOI: 10.1161/circulationaha.112.103879
• Publication Date: 2012-08-14T02:42:55Z
• Authors: Mark Hamer; Severine Sabia; G. David Batty; Martin J. Shipley; Adam G. Tabák; Archana Singh-Manoux; Mika Kivimaki
• Keywords: Adult; Male; Aging; Motor Activity; 796; Cohort Studies; 03 medical and health sciences; 0302 clinical medicine; MESH: C-reactive protein; Humans; Prospective Studies; Exercise; exercise; Interleukin-6; Middle Aged; 16. Peace & justice; United Kingdom; 3. Good health; C-Reactive Protein; inflammation; MESH: C-reactive protein; epidemiology; exercise; inflammation; [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie; Cardiovascular Diseases; epidemiology; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; Female; Biomarkers; Follow-Up Studies

Background— Inflammatory processes are putative mechanisms underlying the cardioprotective effects of physical activity. An inverse association between activity and inflammation has been demonstrated, but no long-term prospective data available. We therefore examined inflammatory markers over a 10-year follow-up period. Methods Results— Participants were 4289 men women (mean age, 49.2 years) from Whitehall II cohort study. Self-reported (serum high-sensitivity C-reactive protein interleukin-6) measured at baseline (1991) (2002). Forty-nine percent participants adhered to standard recommendations for cardiovascular health (2.5 h/wk moderate vigorous activity) across all assessments. Physically active had lower interleukin-6 levels, this difference remained stable time. Compared with who rarely guidelines follow-up, high-adherence group displayed log e (β=−0.07; 95% confidence interval, −0.12 −0.02) −0.10 −0.03) after adjustment range covariates. stable, those reported an increase in least 2.5 (β coefficient=−0.05; −0.001) coefficient=−0.06; −0.09 follow-up. Conclusions— Regular is associated 10 years thus may be important preventing proinflammatory state seen aging.