Arterial Stiffness Impairment in Sickle Cell Disease Associated With Chronic Vascular Complications

• DOI: 10.1161/circulationaha.115.021015
• Publication Date: 2016-09-01T02:33:11Z
• Authors: Brigitte Ranque; Aymeric Menet; Pierre Boutouyrie; Ibrahima Bara Diop; Samuel Kingue; Mamadou Diarra; Roland N’Guetta; Dapa Diallo; Saliou Diop; Ibrahima Diagne; Ibrahima Sanogo; Aissata Tolo; David Chelo; Guillaume Wamba; Jean Paul Gonzalez; Cochise Abough’elie; Cheick Oumar Diakite; Youssouf Traore; Gaëlle Legueun; Indou Deme-Ly; Blaise Felix Faye; Moussa Seck; Boidy Kouakou; Ismael Kamara; Sylvain Le Jeune; Xavier Jouven
• Keywords: Stroke; Acute chest syndrome

Background: Although a blood genetic disease, sickle cell disease (SCD) leads to chronic vasculopathy with multiple organ involvement. We assessed arterial stiffness in SCD patients and looked for associations between SCD-related vascular complications. Methods: The CADRE (Coeur Artères et Drepanocytose, ie, Heart Arteries Sickle Cell Disease) study prospectively recruited pediatric adult healthy controls Cameroon, Ivory Coast, Gabon, Mali, Senegal. Patients underwent clinical examination, routine laboratory tests (complete count, serum creatinine level), urine albumin/creatinine ratio measure, measure of carotid-femoral pulse wave velocity (cf-PWV) augmentation index (AI) at steady state. biological correlates cf-PWV AI were investigated by using multivariable multilevel linear regression analysis individuals nested families further countries. Results: Included 3627 943 controls. Mean was lower (7.5±2.0 m/s) than (9.1±2.4 m/s, P <0.0001), SS-Sβ 0 SC-Sβ + phenotypes. AI, corrected heart rate, increased more rapidly age higher control adults. independently associated age, sex, height, mean pressure, hemoglobin level, country, phenotype. After adjustment these correlates, the glomerular filtration rate osteonecrosis. also stroke, pulmonary hypertension, priapism, microalbuminuria. Conclusions: PWV are deeply modified comparison These changes pressure but Moreover, several Their prognostic value will be follow-up patients.