CD301b/MGL2 + Mononuclear Phagocytes Orchestrate Autoimmune Cardiac Valve Inflammation and Fibrosis

• DOI: 10.1161/circulationaha.117.033144
• Publication Date: 2018-01-31T10:25:33Z
• Authors: Lee A. Meier; Jennifer L. Auger; Brianna J. Engelson; Hannah M. Cowan; Elise R. Breed; Mayra I. Gonzalez...; Joshua D. Boyer; Mayank Verma; Aubyn Marath; Bryce A. Binstadt
• Keywords: Proinflammatory cytokine

Valvular heart disease is common and affects the mitral valve (MV) most frequently. Despite prevalence of MV (MVD), cellular molecular pathways that initiate perpetuate it are not well understood.