Optical Coherence Tomography–Guided or Intravascular Ultrasound–Guided Percutaneous Coronary Intervention: The OCTIVUS Randomized Clinical Trial

• DOI: 10.1161/circulationaha.123.066429
• Publication Date: 2023-08-27T07:14:07Z
• Authors: Do-Yoon Kang; Jung-Min Ahn; Sung-Cheol Yun; Seung-Ho Hur; Yun-Kyeong Cho; Cheol Hyun Lee; Soon Jun Hong; Subin Lim; Sang-Wook Kim; Hoyoun Won; Jun-Hyok Oh; Jeong Cheon Choe; Young Joon Hong; Yong-Hoon Yoon; Hoyun Kim; Yeonwoo Choi; Jinho Lee; Young Won Yoon; Soo-Joong Kim; Jang-Ho Bae; Duk-Woo Park; Seung-Jung Park
• Keywords: Intravascular Ultrasound; Clinical endpoint

Intravascular imaging-guided percutaneous coronary intervention (PCI) with intravascular ultrasound (IVUS) or optical coherence tomography (OCT) showed superior clinical outcomes compared angiography-guided PCI. However, the comparative effectiveness of OCT-guided and IVUS-guided PCI regarding is unknown.In this prospective, multicenter, open-label, pragmatic trial, we randomly assigned 2008 patients significant artery lesions undergoing in a 1:1 ratio to undergo either an The primary end point was composite death from cardiac causes, target vessel-related myocardial infarction, ischemia-driven target-vessel revascularization at 1 year, which powered for noninferiority OCT group IVUS group. Safety were also assessed.At events occurred 25 1005 (Kaplan-Meier estimate, 2.5%) 31 1003 3.1%) (absolute difference, -0.6 percentage points; upper boundary one-sided 97.5% CI, 0.97 P<0.001 noninferiority). incidence contrast-induced nephropathy similar (14 [1.4%] versus 15 [1.5%] group; P=0.85). major procedural complications lower than (22 [2.2%] 37 [3.7%]; P=0.047), although imaging procedure-related not observed.In lesions, noninferior respect year. selected study population lower-than-expected event rates should be considered interpreting trial.URL: https://www.gov; Unique number: NCT03394079.