Abstract P628: Angiotensin 1-7 Mas Receptor and Dopamine D1 receptor Interaction as a Novel Natriuretic Mechanism in Rat Kidneys

• DOI: 10.1161/hyp.66.suppl_1.p628
• Publication Date: 2021-07-03T08:12:47Z
• Authors: Andrea C Diaz Diaz; Mustafa F Lokhand...; Faraz Jafri; Anees A Banday
• Keywords: Kaliuresis

Evidence to date suggests that a positive interaction between natriuretic factors promotes sodium excretion maintain homeostasis and blood pressure. Although the involvement of renal dopamine D1 receptor (D1R) in promoting is well established; role Angiotensin (Ang) 1-7 Mas (MasR) not clear. Here we provide evidence for functional these two G protein-coupled receptors which response Ang via MasR dependent on D1R activation. Male Sprague Dawley rats comparable weight age were infused with 1-7, antagonist DPro, agonist SKF38393 SCH23390. Blood pressure was monitored throughout experimental procedure none drugs affected Animals saline alone served as controls. Infusion Ang1-7 caused significant natriuresis robust diuresis compared saline. infusion also induced when infusion. Both diuretic blocked by Dpro However, failed block response. Concomitant did show cumulative or effect alone. FENa (%), control (saline): 0.30 ± 0.09; 1-7: 1.03 0.21; plus Dpro: 0.49 0.11; SCH23390: 0.36 0.10; SKF38393: 0.83 0.16; 0.41 0.82 0.17; 1.06 0.21. These data suggest causes On other hand, D1R-mediated independent MasR. This study paradigm shift identify novel unidirectional deviates from commonly known receptor-receptor interaction.