Hyperresistinemia Is Associated With Coexistence of Hypertension and Type 2 Diabetes

• DOI: 10.1161/hypertensionaha.107.103077
• Publication Date: 2008-01-08T01:53:35Z
• Authors: Yasunori Takata; Haruhiko Osawa; Mie Kurata; Maki Kurokawa; Junko Yamauchi; Masaaki Ochi; Wataru Nishida; Takafumi Okura; Jitsuo Higaki; Hideichi Makino
• Keywords: Resistin; Essential hypertension

Numerous studies have demonstrated that high blood pressure substantially increases the risk of microvascular and macrovascular complications in patients with type 2 diabetes mellitus (T2DM). Currently, we found serum resistin, an adipocyte- monocyte-derived cytokine, was positively correlated several components metabolic syndrome, including hypertension T2DM. To investigate association resistin etiologic difference among subjects T2DM, without normotensive analyzed 210 subjects, 91 55 64 Serum level higher followed by T2DM irrespective antihypertensive treatment status (20.9+/-17.6 14.0+/-8.9 versus 11.2+/-7.6 ng/mL, respectively; P<0.01). Simple regression analysis revealed (systolic pressure: r=0.29, P<0.01; diastolic r=0.21, P<0.05) intima-media thickness (r=0.27; but not Multiple analysis, adjusted for age, gender, body mass index, fasting glucose, high-density lipoprotein cholesterol, white cell counts, glomerular filtration rate, further independent factor (P<0.05). In vitro gene expression human coronary endothelial cells induced fatty acid binding protein, a key molecule insulin resistance, diabetes, atherosclerosis. These results suggest hyperresistinemia would contribute to pathogenesis significantly linked vascular cardiovascular events.