Left Ventricular Diastolic Dysfunction in the Community: Impact of Diagnostic Criteria on the Burden, Correlates, and Prognosis

• DOI: 10.1161/jaha.117.008291
• Publication Date: 2018-06-01T09:20:47Z
• Authors: Matthew Nayor; Leroy L. Cooper; Danielle M. Enserro; Vanessa Xanthakis; Martin G. Larson; Emelia J. Benjamin; Jayashri Aragam; Gary F. Mitchell; Ramachandran S. V...
• Keywords: Framingham Heart Study

Background Left ventricular diastolic dysfunction ( DD ) is common, particularly in women and older individuals, it associated with adverse cardiovascular outcomes. We evaluated the impact of age‐ sex‐specific diagnostic criteria on assessment community‐based Framingham Heart Study. Methods Results estimated reference limits for echocardiographic measures a healthy subsample (N=2355, mean age 44 years, 66% women). The prevalence, correlates, association future disease were compared using versus single cut point broad sample (N=6102, 50 56% Using criteria, was present ≈25% to 30% individuals across groups, directly number modifiable risk factors. In contrast, primary determinant . During follow‐up (mean 7.9±2.2 years), incident occurred 213 5770 individuals. mild moderate‐severe 50% (95% confidence interval, 1.09–2.05) 65% 1.14–2.38) higher incidences disease, respectively, sex‐adjusted analyses. With (hazard ratio, 1.66; 95% 1.05–2.61), but not 0.94; 0.63–1.40), disease. Conclusions Age‐ may result assessments that are less dependent age, more robustly related factors, closely