Comprehensive Review of Tenecteplase for Thrombolysis in Acute Ischemic Stroke

• DOI: 10.1161/jaha.123.031692
• Publication Date: 2024-04-30T11:27:45Z
• Authors: Liyuan Wang; Manjun Hao; Na Wu; Shuangzhe Wu; Marc Fisher; Yunyun Xiong
• Keywords: Tenecteplase; Fibrinolytic agent; Stroke

Although intravenous thrombolysis with alteplase remains the primary treatment for acute ischemic stroke, tenecteplase has shown potential advantages over alteplase. Animal studies have demonstrated favorable pharmacokinetics and pharmacodynamics of tenecteplase. Moreover, it is easier to administer. Clinical trials that not inferior may even be superior in cases stroke large vessel occlusion. Current evidence supports time cost benefits tenecteplase, suggesting could potentially replace as main option thrombolytic therapy, especially patients