Aortic Stenosis and Renal Function: A Bidirectional Mendelian Randomization Analysis

• DOI: 10.1161/jaha.123.034102
• Publication Date: 2024-04-19T11:09:56Z
• Authors: Jonathan L. Ciofani; Daniel Han; Usaid K. Allahwala; Ravinay Bhindi
• Keywords: Mendelian Randomization

Large observational studies have demonstrated a clear inverse association between renal function and risk of aortic stenosis (AS). Whether this represents causal, reverse causal or correlative relationship remains unclear. We investigated using bidirectional 2-sample Mendelian randomization approach.