High‐Normal Serum Potassium, Calcium, and Magnesium Levels Are Associated With Decreased Risks of Adverse Outcomes After Ischemic Stroke

• DOI: 10.1161/jaha.124.037601
• Publication Date: 2025-05-13T09:45:33Z
• Authors: Quan Yu; Yang Liu; Xinyue Chang; Xueyu Mao; Xuechun Wu; Min Chu; Huicong Niu; Mengyao Shi; Lulu Sun; Yu He; Yi Liu; Daoxia Guo; Zhengbao Zhu; Jing Zhao
• Keywords: Stroke; Quartile

Background High serum potassium, calcium, and magnesium levels have been reported to be associated with decreased risks of ischemic stroke, whereas their prognostic values in stroke remain unclear. We aimed prospectively explore the associations prognosis stroke. Methods measured at baseline among 5469 patients from Minhang Stroke Cohort study. The primary outcome was composite death major disability (modified Rankin Scale score ≥3) 3 months after Secondary outcomes included disability, death, ordered 7‐level categorical modified Scale. Results During 3‐month follow‐up, 1834 developed outcome. After multivariate adjustment, adjusted odds ratios for highest versus lowest quartile were 0.79 (95% CI, 0.68–0.93; P trend =0.007) 0.69 0.58–0.82; <0.001) 0.83 0.70–0.99; =0.015) magnesium. Multivariable‐adjusted restricted cubic spline analyses showed linear dose–response relationships risk (all linearity<0.05). Conclusions High‐normal adverse suggesting that might valuable biomarkers