Global, Regional, and National Burden of Valvular Heart Disease, 1990 to 2021

• DOI: 10.1161/jaha.124.037991
• Publication Date: 2024-12-14T09:13:27Z
• Authors: Qin‐Fen Chen; Shanzhen Shi; Yu‐Fei Wang; Jingjing Shi; Chenyang Liu; Tiancheng Xu; Chao Ni; Xi Zhou; Weihong Lin; Yangdi Peng; Xiao‐Dong Zhou
• Keywords: valvular heart disease; Demographics; Disability-adjusted life year

Background Valvular heart disease poses an escalating global health challenge with increasing impact on mortality and disability. This study aims to comprehensively analyze the burden of valvular disease. Methods Results Using Global Burden Disease 2021 data, we analyzed prevalence disability‐adjusted life years, examining implications across demographics geographic regions. In 2021, estimated 54.8 million (95% uncertainty interval [UI], 43.3–67.6) cases rheumatic disease, 13.3 UI, 11.4–15.2) nonrheumatic calcific aortic valve (CAVD), 15.5 14.5–16.7) degenerative mitral (DMVD) were reported globally. Despite rising prevalence, years declined between 1991 2021. Among individuals aged 70 or older, age‐standardized prevalences 1803.6 per 100 000 1535.5–2055.7) for CAVD 2148.9 2001.4–2310.1) DMVD. Sub‐Saharan Africa had highest disease; Conversely, high‐income regions led in DMVD prevalence. Rheumatic 1184.2 932.4–1478.2) low Socio‐Demographic Index (SDI) regions, whereas peaked at 349.8 303.6–395.8) high SDI The most substantial increases from 1990 occurred middle low‐middle A parallel trend was noted Conclusions remains a significant pose challenges aging populations.