Abstract 273: Levels Of Vcam-1 Are Associated With Flow-mediated Dilation In Healthy African American Adults

• DOI: 10.1161/res.113.suppl_1.a273
• Publication Date: 2021-07-03T10:24:21Z
• Authors: CHENYI LING; Sheara Williamson; Keith Diaz; Jan Kretzschmar; Deborah Feairheller; Kathleen Sturgeon; Praveen Veerabhad...; Amanda Perkins; Hojun Lee; Heather Grimm; Abul Kashem; Dianne Babbitt; Michael Brown
• Keywords: Endothelial Dysfunction; VCAM-1; Endothelial Activation; Brachial artery

Background: Vascular cell adhesion molecule-1 (VCAM-1) mediates the of monocytes to vascular endothelium, which play a role in development endothelial dysfunction and atherosclerosis. Flow-mediation dilation (FMD) is an endothelium-dependent response, mediated by nitric oxide closely related function. The purpose study was test whether levels VCAM-1 were associated endothelial-dependent normotensive African Americans. Normotensives studied order eliminate influence hypertension. Methods Results: Blood collected 22 subjects aged 41-62 yrs with normal blood pressure (125.0 ± 9.1 mmHg) after 12 hr fast. Plasma obtained centrifugation within 15 min collection 4 degree. A commercially available solid phase sandwich enzyme linked immuno-sorbent assay kit used detect plasma. FMD measured 5-min cuff occlusion using Doppler ultrasound. maximum diameters calculated. In entire population, (556.92 154.20 ng/mL) negatively correlated true peak (FMD: 7.81 2.22 %, r=-0.484, P=0.023). Conclusion: Levels responsiveness healthy Americans pressure. These results suggest that level may be predictive unique populations.