Abstract WP32: Heterogeneity of Oxygen Extraction Fraction Weighted MRI in Acute Ischemic Stroke Patients

• DOI: 10.1161/str.44.suppl_1.awp32
• Publication Date: 2021-07-03T12:02:14Z
• Authors: Ona Wu; William A Copen; Kenneth K Kwong; Oguzhan Kursun; Steven Mocking; Thomas Benner; Timothy G Reese; Pamela W Schaefer; Aneesh B Singhal
• Keywords: Stroke

Background: Increases in oxygen extraction fraction (OEF) are postulated to be a marker of tissue at risk infarction acute ischemic stroke patients. R2’, parameter that can measured rapidly using an asymmetric spin echo MRI sequence (ASE), considered OEF-weighted metric, being combination both OEF and venous cerebral blood volume. We investigated the feasibility utility stroke. Methods: Adult patients were prospectively enrolled 3T study imaged within 48 hours onset. Only subset whose included ASE DWI was positive for analyzed. Acquisition time 1.5 min. R2’ maps calculated from data on voxel-wise basis after motion correction smoothing. follow-up images (FU), when available, co-registered ASE. Mean values coefficient variance (mean/SD) lesion, ipsilateral DWI-normal (IPS) contralesional hemisphere (CNL) compared. Results: Fifteen subjects met inclusion criteria with mean±SD age 64±14 years, median admission NIHSS 12 [IQR 7-15] onset 39±30 h. Eleven tPA therapy. Both elevated decreased observed FU lesions. lesion (6.0±1.5 Hz) significantly lower than CNL (7.2±0.6 Hz, P=0.02) IPS (7.2±0.7 P=0.01). Coefficient also (P=0.03) or (P=0.05). For imaging, mean eventually infarcted (5.7±1.8 (P=0.02) surrounding (7.3±0.6 but not (6.1±1.6 Hz). Discussion: In this ASE, potentially reflect is destined since proportional metabolic rate. Increased may sign infarction. Studies including measures CBF CBV will allow better discrimination status.