Abstract WP127: Cerebral Microbleeds, Cerebral Amyloid Angiopathy, And Their Relationships To Quantitative Markers Of Neurodegeneration

• DOI: 10.1161/str.53.suppl_1.wp127
• Publication Date: 2022-02-03T10:01:59Z
• Authors: Charles Beaman; Khrystyna Kozii; Saima Hilal; Minghua Liu; Antonio Spagnolo-...; Christopher Chen; Ching-Yu Cheng; Daniela Zambrano; Burak Arikan; Victor J Del Brutto; Clinton Wright; Xena E Flowers; Sandra P Leskinen; Tatjana Rundek; Amanda Mitchell; Jean Paul Vonsattel; Etty Cortes; Andrew F Teich; Ralph L Sacco; Mitchell S Elkind; David Roh; Jose Gutierrez
• Keywords: Neuropathology; Cognitive Decline

Introduction: Age-related cognitive impairment is driven by the complex interplay of neurovascular and neurodegenerative disease. There a strong relationship between cerebral microbleeds (CMBs), amyloid angiopathy (CAA), decline observed in conditions such as Alzheimer’s In early, preclinical phase impairment, extent to which CMBs underlying CAA impact volumetric changed brain related disease remains unclear. Methods: We performed cross-sectional analyses from 3 large cohorts: The Northern Manhattan Study (NOMAS), Disease Neuroimaging Initiative (ADNI), Epidemiology Dementia Singapore study (EDIS). conducted confirmatory analysis 82 autopsied cases Brain Arterial Remodeling (BARS). implemented multivariate regression association two markers cerebrovascular – MRI-based autopsy-based CAA, independent variables, neurodegeneration, dependent variables. Results: included 2657 participants with available MRI data autopsy BARS. meta-analysis NOMAS, ADNI EDIS, superficial were associated larger gray (β=4.49 ± 1.13, P=0.04) white (β=4.72 2.1, P=0.03) matter volumes. volume was more evident one CMB (B=5.17 2.47, than those ≥ 2 (β=1.97 3.41, P=0.56). BARS, increased cortical thickness (β = 6.5 2.3, P=0.016) but not weight (β=1.54 1.29, P=0.26). Discussion: Superficial are morphometric measures. This strongest brains fewer CMBs, suggesting that CMBs/CAA contribution neurodegeneration may relate tissue loss, at least early stages