Abstract 36: Association Between High-Resolution Magnetic Resonance Imaging Characteristics and Recurrent Stroke in Patients With Symptomatic Intracranial Atherosclerotic Steno-Occlusive Disease: A Prospective Multicenter Study

• DOI: 10.1161/str.55.suppl_1.36
• Publication Date: 2024-02-01T10:11:28Z
• Authors: Weizhuang Yuan; Liu Xiaoyun; Zhongrui Yan; Bo Wu; Baoquan Lu; Beilei Chen; Daishi Tian; Ailian Du; Litao Li; Changyun Liu; Guangzhi Liu; Gong Tao; Zhimin Shi; Feng Feng; Caiyan Liu; Meng Yao; Qianqian Lin; Mingli Li; Xu Wei-hai
• Keywords: Stroke; Occlusive

Background and Objectives: This study aimed to investigate the association between high-resolution magnetic resonance imaging (HR-MRI) characteristics recurrent ipsilateral stroke in patients with symptomatic intracranial atherosclerotic steno-occlusive disease (ICAS). Methods: multicenter, observational recruited first-ever acute ischemic attributed ICAS (>50% stenosis or occlusion) within 7 days after onset. Participants were assessed by multi-parametric MRI including diffusion-weighted imaging, three-dimension time-of-flight angiography, three-dimensional T1-weighted HR-MRI. The recommended receive best medical therapy systematically followed up for 12 months. HR-MRI time was investigated univariable multivariable analysis. Results: Two hundred fifty-five consecutive enrolled from 15 centers. cumulative 12-month recurrence incidence 4.1% (95% confidence interval [CI]: 1.6-6.6%). plaque length (5.69±2.21 mm vs. 6.67±4.16 mm), burden (78.40±7.37% 78.22±8.32%), degree of (60.25±18.95% 67.50±22.09%) remodeling index (1.07±0.27 1.03±0.35) on did not exhibit discernible difference without stroke. Patients exhibited higher rates intraplaque hemorrhage (IPH) (30.0% 6.5%) eccentric (90.0% 48.2%), lower occurrence occlusive thrombus (10.0% 23.7%). In Cox regression analysis, IPH (hazard ratio: 7.05, 95% CI: 1.53-32.41, p=0.012) significantly associated adjustment. Discussion: We found is Our results suggest has potential value selection aggressive treatment strategies.