Abstract 57: Rapid Prehospital Diagnosis of Intracerebral Hemorrhage by Measuring GFAP on a Point-of-Care Platform

• DOI: 10.1161/str.55.suppl_1.57
• Publication Date: 2024-02-01T10:11:28Z
• Authors: Love-Preet Kalra; Sabina Zylyftari; Kristaps Blums; Stephan Barthelmes; Sebastian Humm; Hannsjoerg Baum; Stephan Meckel; Sebastian Luger; Christian Foerch
• Keywords: Point of care; Point-of-Care Testing; Stroke; Neurointensive care

Background: The rapid differentiation between intracerebral hemorrhage (ICH) and ischemic stroke (IS) in patients with symptoms of acute is decisive for triage initiation targeted therapies. Glial fibrillary acidic protein (GFAP) a highly promising blood biomarker indicating ICH. In this study we investigated the potential new GFAP plasma test on point-of-care (POC) platform rapidly distinguishing ICH from IS prehospital phase. Methods: Patients admitted within 6 hours symptom onset were enrolled. Blood samples collected already phase most patients. Plasma measurements performed i-STAT Alinity® (Abbott) device (duration analysis 15 min). primary endpoint was final diagnosis at hospital discharge categorized as ICH, or mimics. Results: 155 enrolled (mean age 75±13, 49% females; 33 115 IS, 7 mimics). Prehospital serum concentrations strongly elevated compared to 2283±3821 pg/mL, median 144 [IQR 52.5-2562] vs. mean 45±25 29 29-53]; p<0.001). moderate severe neurological deficit (NIHSS > 7), values below 30 pg/mL associated negative predictive value 100% (i.e. ruling out ICH). probability increased parallel higher levels. above 120 indicated positive 94%. Conclusion: Rapid allow reliable This opens optimized administration antidots severely affected suspected anticoagulation-associated