Abstract TMP67: Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy May Affect Large Cerebral Arteries

• DOI: 10.1161/str.55.suppl_1.tmp67
• Publication Date: 2024-02-01T10:11:28Z
• Authors: Edgar R Lopez-Nav...; Silvia V Mayer; Brenno R Barreto; Pedro Bueno; Kursat Gurel; Farid Khasiyev; Khrystyna Kozii; Salwa Rahman; Antonio Spagnolo-...; J P Mohr; Jose Gutierrez
• Keywords: CADASIL; Cervical Artery; Stroke; Lacunar stroke

Introduction: CADASIL is the most common monogenic small-vessel disease (SVD) form. Large and small brain arteries are intimately related, but it unclear whether people with have changes in their large as a result. We hypothesized that patients affected compared to controls. Methods: conducted comparative analysis by matching 37 104 lacunar stroke from NYP/ Columbia University Medical Center Stroke Registry Study matched age +/-3 sex. measured basilar intracranial carotid artery diameters both groups T2 MRI images. rated cervical tortuosity 0 for no tortuosity, 1 45-90°, 2 >90°. ran generalized linear models compare cases controls, adjusting demographics clinical variables. Results: Patients were less likely Hispanic\Latino (10.8% vs. 51.9%, p=<0.001), hypertensive (27% 73.1%, current smokers (5.4%vs. 22.1%, p=0.024), more prior (56.8% 24%, p=<0.001) than controls—Table 1. In adjusted model, had larger (p=0.007) statistical trend greater tortuosity—Table 2. Conclusions: Although traditionally considered an example of pure SVD, higher prevalence dilatation. Whether result or part NOTCH3 mutation phenotype uncertain. Further investigation needed determine if involvement influences manifestations CADASIL.