Abstract WP158: Cortical Superficial Siderosis is Associated With Ischemia After Intracerebral Hemorrhage

• DOI: 10.1161/str.55.suppl_1.wp158
• Publication Date: 2024-02-01T10:11:28Z
• Authors: Mohamed Ridha; Marialaura Simonetto; Fernanda Carvalho...; Evan Hess; Aditya Kumar; Sachin Agarwal; Shivani Ghoshal; Jan Claassen; Edward Connolly; Soojin Park; David Roh
• Keywords: Superficial siderosis; Siderosis; Stroke

Background: Ischemia on diffusion weighted imaging (DWI) after intracerebral hemorrhage (ICH) increases the risk of future ischemic stroke. Radiographic markers small vessel disease, including cerebral microbleeds (CMB), are associated with DWI lesions. Though cortical superficial siderosis (cSS) is also a hemorrhagic disease subtype, it unclear if cSS similarly relates to We hypothesized that would represent more severe phenotype and associate lesions ICH independent other markers. Methods: Using Intracerebral Hemorrhage Outcomes Project (ICHOP), we included all cases spontaneous who underwent susceptibility imaging/gradient echo. hyperintensities were identified >10mm from hematoma decreased ADC signal. as subarachnoid hemosiderin deposition without acute hemorrhage. The relationship lesion presence outcome was assessed logistic regression adjusted for score, blood pressure change within 24 hours, (CMB white matter hyperintensity). Sensitivity analyses performed adjust demographics location. A secondary analysis using linear association number similar covariates. Results: Of 198 patients analyzed, observed in 31.3% 10.6%. (adjusted OR 3.72, CI: 1.29-10.72), Separate sensitivity adjusting sex, race, location did not In analyses, greater counts (b 0.213, CI -0.53-0.63). Discussion: lesions, may recurrence ischemia. Further work required investigate underlying mechanisms optimal strategies mitigate competing risks events these patients.