Abstract 47: Rapid prehospital diagnosis of intracerebral hemorrhage in acute stroke patients by measuring GFAP on a point-of-care platform (DETECT study)

• DOI: 10.1161/str.56.suppl_1.47
• Publication Date: 2025-01-30T10:21:51Z
• Authors: Love-Preet Kalra; Sabina Zylyftari; Kristaps Blums; Stephan Barthelmes; Hannsjoerg Baum; Stephan Meckel; Andreas Heilgeist; Sebastian Luger; Christian Foerch
• Keywords: Stroke; Point of care; Acute stroke; Point-of-Care Testing

Introduction: The rapid identification of acute intracerebral hemorrhage (ICH) in patients with symptoms stroke is decisive for prehospital triage and initiation targeted therapies. Glial fibrillary acidic protein (GFAP) a highly promising blood biomarker indicating ICH. In this study we investigated the potential new GFAP point-of-care test rapidly distinguishing ICH from ischemic (IS) mimics phase. Methods: Acute admitted within 6 hours symptom onset were enrolled. Blood samples collected Plasma measurements performed on i-STAT Alinity® (Abbott) device (duration analysis 15 min). gold standard was final diagnosis at hospital discharge categorized as ICH, IS or mimics. Results: 353 enrolled (mean age 74.6 ±13.4, years). concentrations strongly elevated (n=76; median 208 pg/mL [IQR 60 – 5907]) compared to (n=258; 30 29-51]) (n=19; 48 29-97]; p<0.001). Patients anticoagulation-associated had higher values non-anticoagulated patients. Cut-off points determined allowing across distinct groups high positive predictive (90.0 95.5%). Vice versa, moderate severe neurological deficit (NIHSS > 6), below ruled out negative value 100.0 %. Conclusion: Prehospital platform allow reliable This opens optimized well pressure lowering therapy anticoagulation reversal earlier time frames.