Abstract TP207: Cerebral Amyloid Angiopathy Prevalence and Risk of Future Cerebrovascular Events and Mortality in Patients Presenting with Possible Transient Ischemic Attack

• DOI: 10.1161/str.56.suppl_1.tp207
• Publication Date: 2025-01-30T10:11:28Z
• Authors: Samuel Bruce; Parisa Heidari; Pasquale Castigliego; Sofiya Shamailova; Luiz Alexandre Da...; Babak Navi; Santosh Murthy; Hooman Kamel; Christoph Kurmann; Johannes Kaesmacher; Martina Goeldlin; Simon Jung; David Seiffge; Urs Fischer; Philipp Buecke; Ava Liberman; Morin Beyeler
• Keywords: Stroke; Transient (computer programming); Angiopathy

Introduction: Cerebral amyloid angiopathy (CAA) can present with transient focal neurological episodes and is itself associated a heightened risk of intracerebral hemorrhage (ICH). Therefore, in patients suspected ischemic attack (TIA), CAA impact diagnostic evaluation antithrombotic management. However, among presenting possible TIA, there are few data on the prevalence its future cerebrovascular events mortality. Methods: We retrospectively analyzed consecutive to Bern University Hospital, Switzerland between 2015 2019 reversible deficits lasting <24 hours no evidence acute ischemia brain MRI. Two neurologists reviewed these patients’ MRI scans evaluate for according Boston Criteria, v2.0. Long-term outcomes included mortality, which was determined through Swiss Population Registry, subsequent (ICH, stroke, TIA), were assessed via electronic health record review. Cox regression models used association or probable after adjustment age, sex, ABCD2 score, use at discharge. Results: Of 1,117 subjects during study period symptoms MRI, 21 (2%) met radiographic criteria 30 (3%) CAA. During median follow up 4.8 (interquartile range, 3.3-6.3) years, 7 (1%) had an ICH, 62 (5%) stroke , 72 (6%) 181 (16%) died. In multivariable analysis, (adjusted hazard ratio [aHR], 0.94; 95% CI, 0.37-2.35) mortality (aHR, 1.30; 0.83-2.01). Conclusions: cohort 5%. did not find Further studies needed inform optimal management meeting deficits.