Abstract WP124: Three-year Follow-up Quantitative MRI And Recovery Assessment After Endovascular Treatment In Acute Ischemic Stroke

• DOI: 10.1161/str.56.suppl_1.wp124
• Publication Date: 2025-01-30T10:15:32Z
• Authors: Praneeta Konduri; Dimitrios Karkalo...; Stefan Roosendaal; Maarten Lahr; Chi Nguyen; Henk Marquering; Charles Majoie; Luka Liebrand; Matthan Caan
• Keywords: Stroke; Acute stroke; Stroke Recovery; Brain ischemia

Introduction: Long term (>36 months) recovery after endovascular treatment (EVT) remains largely understudied in acute ischemic stroke (AIS) patients. Previously, we have shown that long-term white matter microstructure damage, iron deposition and atrophy within/remote to the 24-hour lesion could influence long quality of life. However, role baseline characteristics on status perform daily activities is unknown. Methods: We executed a quantitative 3T MRI protocol (FLAIR, diffusion MRI, R1, R2*, Quantitative Susceptibility Mapping, Arterial Spin Labeling) 37 (IQR: 28-38) months patients from MR CLEAN No-IV trial who received post-EVT (DWI, FLAIR, SWI). Lateral ventricular volume difference was computed at both time-points quantify atrophy. also used (R2*) subcortical nuclei relative contralateral nuclei. defined using activity scores EQ5D5 questionnaire. A Bayesian paired T-test lateral between performed, correlation clinical with outcomes (Bayes Factor (BF)<3: no/weak; BF>3: moderate; BF>20: strong evidence). Results: included 24 protocol. Median age 64 (51-75) years, 11 (46%) were randomized receive intravenous thrombolysis (IVT) prior EVT, 19 (79%) had an MCA occlusion. Functional independence (mRS 0-2) 90 days (21 (88%) patients) (20 (83%) comparable. Ventricular observed (BF=4.10 5 ), higher blood pressure poorer collaterals associated larger (BF: 11, 4.3 respectively). Lower ASPECTS thalamic (BF=111, Lastly, lower hippocampal reduced (BF=26, BF=4). Conclusion: While functional our cohort comparable over time, baseline, clinical, point brain degradation, which turn impacts ability activities.