Abstract WP15: Intravenous Thrombolysis in Cervical Artery Dissection-Related Stroke: A Nationwide Study

• DOI: 10.1161/str.56.suppl_1.wp15
• Publication Date: 2025-01-30T10:21:51Z
• Authors: Liqi Shu; Elizabeth Lee; Thalia Field; Xiaofan Guo; Nils Henninger; Zafer Keser; Muhib Khan; Eva Mistry; Thanh Nguyen; James Siegler; Lukas Strelecky; Daniel Mandel; Christoph Stretz; Farhan Khan; Karen Furie; Shadi Yaghi
• Keywords: Cervical Artery; Stroke; Vertebral artery dissection; Artery dissection

Introduction: The safety and efficacy of intravenous thrombolysis (IVT) in cervical artery dissection-related acute ischemic stroke (CeAD-AIS) remains unclear. We performed a retrospective study data from the National Inpatient Sample investigating outcomes CeAD-AIS patients treated with without IVT. Methods: included adult hospitalized between 2016 to 2019. was defined by concurrent CeAD AIS diagnoses, identified ICD-10 codes. primary outcome home discharge. were inpatient death intracerebral hemorrhage (ICH). used survey-weighted multivariable adjusted logistic regressions comparing groups (IVT versus no IVT), followed interaction analyses examine for effect modifications based on age, medical history, severity, endovascular treatment. Results: Between 2016-2019, 1,360 (12.1%) 11,285 received Patients IVT- had higher NIH Stroke Scale (NIHSS) scores (median 8 [4-17] 3 [1-11]; p < 0.001). In analyses, treatment IVT associated greater odds discharge (adjusted ratio [aOR] 1.49; 95% confidence interval [CI] 1.09-2.05, = 0.014), but not ICH (aOR 0.90, CI 0.43-1.86, 0.773) or 1.22, 0.72-2.06, 0.454). severity significantly interacted ( 0.001), where increased likelihood moderate severe strokes (NIHSS > 4) 2.28, 1.59-3.26, 0.001) those mild 0-4) 1.03 0.62-1.70, 0.922). Conclusion: improved increasing risk ICH.