Continuous Positive Airway Pressure Ventilation for Acute Ischemic Stroke

• DOI: 10.1161/strokeaha.111.637611
• Publication Date: 2011-12-24T02:03:07Z
• Authors: Jens Minnerup; Martin Andreas Ri...; Heike Wersching; André Kemmling; Angelika Okegwo; Antje Schmidt; Matthias Schilling; E. Bernd Ringelstein; Wolf Rüdiger Schä...; Peter Young; Rainer Dziewas
• Keywords: Stroke; Apnea–hypopnea index; Positive airway pressure

Sleep-related breathing disorders occur frequently after stroke. We assessed the feasibility of continuous positive airway pressure (CPAP) treatment initiated in first night stroke.In this open-label, parallel-group trial, 50 patients were randomly assigned to CPAP therapy or control group. All underwent polysomnography fourth night. Intervention received for 3 nights starting stroke onset and an additional 4 when revealed apnea-hypopnea index >10/hour. The primary end point was defined as reduction under treatment, nursing workload, adherence.The significantly reduced (32.2±25.3-9.8±6.6, P=0.0001). Nursing workload did not differ between (n=25) group (n=25; P=0.741). Ten (40.0%) had excellent use, 14 (56.0%) some 1 patient (4.0%) no use. There a trend toward greater National Institutes Health Stroke Scale score improvement until Day 8 on (2.00 versus 1.40, P=0.092) with use compared (2.30 P=0.022).CPAP seems be feasible associated neurological deterioration. Clinical Trial Registration- URL: www.clinicaltrials.gov. Unique identifier: NCT00151177.