High Levels of S100A12 Are Associated With Recent Plaque Symptomatology in Patients With Carotid Atherosclerosis

• DOI: 10.1161/strokeaha.111.642256
• Publication Date: 2012-03-03T18:25:18Z
• Authors: Azhar Abbas; Pål Aukrust; Tuva B. Dahl; Vigdis Bjerkeli; Ellen B. Lund Sagen; Annika Michelsen; David Russell; Kirsten Krohg-Sør...; Sverre Holm; Mona Skjelland; Bente Halvorsen
• Keywords: S100A8; S100A9

Atherosclerosis is a progressive chronic disease, in which inflammation plays key role. The calcium-binding proteins calgranulins including S100A8, S100A9, and S100A12 are involved many cellular activities pathological processes inflammation. We therefore hypothesized that may be markers of plaque instability patients with carotid atherosclerosis.Plasma levels S100A8/A9 S100A10 were measured 159 consecutive high-grade stenosis 22 healthy control subjects. mRNA also within the atherosclerotic plaques, their regulation was analyzed vitro monocytes.Our main findings were: (1) plasma significantly higher atherosclerosis compared subjects highest most recent symptoms (ie, 2 months); (2) S100A8/S100A9 showed modest increase previous to 6 months but not other patients; (3) increased expression plaques from remaining (4) THP-1 monocytes, activation Toll-like receptors 4 S10012 interleukin-1β, interferon γ, releasate thrombin-activated platelets enhanced S100A12.Our support link between atherogenesis suggest these mediators, particular S100A12, related instability.