Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke

• DOI: 10.1161/strokeaha.111.675918
• Publication Date: 2013-05-29T06:51:50Z
• Authors: Andrea Rocco; Peter U. Heuschmann; Peter D. Schellinger; Martin Köhrmann; Jennifer Diedler; Marek Sykora; Christian H. Nolte; Peter Ringleb; Werner Hacke; Eric Jüttler
• Keywords: Stroke; Univariate analysis

Symptomatic intracerebral hemorrhage (sICH) is the most feared acute complication after intravenous thrombolysis. The aim of this study was to determine predictive value parameters glycosylated hemoglobin A1 (HbA1c) on sICH.In a retrospective single center series, 1112 consecutive patients treated with thrombolysis were studied. Baseline blood glucose obtained at admission. HbA1c determined within hospital stay. A second head computed tomography 24 hours or when neurological worsening occurred. Modified Rankin Scale used assess outcome 90 days.A total 222 (19.9%) had any hemorrhage; 43 those sICH (3.9%) per Safe Implementation Treatments in Stroke definition and 95 (8.5%) National Institute Neurological Disorders definition; 33.2% dependent (modified score 3-5). In univariate analysis history diabetes mellitus, HbA1c, glucose, Health admission associated sICH. multivariate score, predictors Stroke, only criteria used.In our study, turns out be an important predictor for stroke. These results suggest that may consequence long-term vascular injury rather than hyperglycemia, better mellitus.