Statin Use and Microbleeds in Patients With Spontaneous Intracerebral Hemorrhage

• DOI: 10.1161/strokeaha.112.657486
• Publication Date: 2012-07-25T06:09:26Z
• Authors: Diogo C. Haussen; Nils Henninger; Sandeep Kumar; Magdy Selim
• Keywords: Stroke; Hydroxymethylglutaryl-CoA Reductase Inhibitors

Statins have been associated with increased risk of intracerebral hemorrhage (ICH), particularly in elderly patients previous ICH. Recurrent ICH the is often related to cerebral amyloid angiopathy. Therefore, we investigated whether statin use prevalence and severity microbleeds (MB), cortico-subcortical (csMB), which are frequently observed angiopathy.We studied 163 consecutive spontaneous who underwent magnetic resonance imaging within 30 days presentation. We retrieved clinical information analyzed for presence, location, number MB, were divided into csMB or other (other MB). performed group comparisons stratified by presence vs absence any MB (csMB and/or MB) alone.Sixty-four percent had lobar Overall, 53% 39% csMB. Statin users older, significantly lower cholesterol low-density lipoprotein levels, higher hypertension, diabetes, dyslipidemia, antiplatelet use. The similar statin-treated statin-untreated individuals. However, more (57% 33%; P=0.007), almost twice as many lesions (4.6 ± 11.3 2.4 8.0; P=0.007) compared untreated patients. Age independently both (odds ratio [OR], 1.03; 95% confidence interval [CI], 1.00-1.05; P=0.01 OR, 2.72; CI. 1.02-7.22; P=0.04, respectively) (OR, CI, 1.00-1.06; 4.15; 1.54-11.20; P<0.01) multivariate analyses.Statin especially Future studies needed confirm our findings investigate can serve a surrogate marker