Contribution of Established Stroke Risk Factors to the Burden of Stroke in Young Adults

• DOI: 10.1161/strokeaha.117.016599
• Publication Date: 2017-06-16T01:10:21Z
• Authors: Annette Aigner; Ulrike Grittner; Arndt Rolfs; Bo Norrving; Bob Siegerink; Markus A. Busch
• Keywords: Stroke

Background and Purpose— As stroke in young adults is assumed to have different etiologies risk factors than older populations, the aim of this study was examine contribution established potentially modifiable cardiovascular burden adults. Methods— A German nationwide case–control based on patients enrolled SIFAP1 (Stroke In Young Fabry Patients) 2007 2010 controls from population-based GEDA (German Health Update) 2009 performed. Cases were 2125 consecutive aged 18 55 years with acute first-ever 26 clinical centers; (age- sex-matched, n=8500, without previous stroke) a community sample. Adjusted population-attributable risks 8 (hypertension, hyperlipidemia, diabetes mellitus, coronary heart disease, smoking, heavy episodic alcohol consumption, low physical activity, obesity) their combinations for all stroke, ischemic primary intracerebral hemorrhage calculated. Results— Low activity hypertension most important factors, accounting 59.7% (95% confidence interval, 56.3–63.2) 27.1% 23.6–30.6) strokes, respectively. All combined explained 78.9% 76.3–81.4) strokes. Population-attributable similar subtypes. higher age groups men. Conclusions— Modifiable previously populations also account large part younger adults, 4 explaining almost 80% risk. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00414583.