Cognitive Impairment Before Intracerebral Hemorrhage Is Associated With Cerebral Amyloid Angiopathy

• DOI: 10.1161/strokeaha.117.019409
• Publication Date: 2017-12-15T10:05:32Z
• Authors: Gargi Banerjee; Duncan Wilson; Gareth Ambler; Karen Osei-Bonsu ...; Clare Shakeshaft; Surabhika Lunawat; Hannah Cohen; Tarek Yousry; Gregory Y.H. Lip; Keith W. Muir; Martin M. Brown; Rustam Al-Shahi S...; Hans Rolf Jäger; David J. Werring; Louise Shaw; Jane Sword; Azlisham Mohd Nor; Pankaj Sharma; Roland Veltkamp; Deborah Kelly; Frances Harrington; Marc Randall; Matthew Smith; Karim Mahawish; Abduelbaset Elmarim; Bernard Esisi; Claire Cullen; Arumug Nallasivam; Christopher Price; Adrian Barry; Christine Roffe; John Coyle; Ahamad Hassan; Caroline Lovelock; Jonathan Birns; David Cohen; L. Sekaran; Adrian Parry-Jones; Anthea Parry; David Hargroves; Harald Proschel; Prabel Datta; Khaled Darawil; Aravindakshan Manoj; Mathew Burn; Chris Patterson; Elio Giallombardo; Nigel Smyth; Syed Mansoor; Ijaz Anwar; Rachel Marsh; Sissi Ispoglou; Dinesh Chadha; Mathuri Prabhakaran; Sanjeevikumar Mee...; Janice O’Connell; Jon Scott; Vinodh Krishnamurthy; Prasanna Aghoram; Michael McCormick; Paul O’Mahony; Martin Cooper; Lillian Choy; Peter Wilkinson; Simon Leach; Sarah Caine; Ilse Burger; Gunaratam Gunathi...; Paul Guyler; Hedley Emsley; Michelle Davis; Dulka Manawadu; Kath Pasco; Maam Mamun; Robert Luder; Mahmud Sajid; Ijaz Anwar; James Okwera; Julie Staals; Elizabeth Warburton; Kari Saastamoinen; Timothy England; Janet Putterill; Enrico Flossman; Michael Power; Krishna Dani; David Mangion; Appu Suman; John Corrigan; Enas Lawrence; Djamil Vahidassr
• Keywords: Superficial siderosis; Cognitive Decline

Although the association between cerebral amyloid angiopathy (CAA) and cognitive impairment is increasingly recognized, it not clear whether this because of impact recurrent intracerebral hemorrhage (ICH) events, disruptions caused by small vessel damage, or both. We investigated considering before ICH was associated with neuroimaging features CAA on magnetic resonance imaging.We studied 166 patients neuroimaging-confirmed recruited to a prospective multicentre observational study. Preexisting determined using Informant Questionnaire Cognitive Decline in Elderly (IQCODE). Magnetic imaging markers disease, including CAA, were rated trained observers according consensus guidelines.The prevalence 24.7% (n=41) and, adjusted analyses, fulfilling modified Boston criteria for probable at presentation (odds ratio, 4.01; 95% confidence interval, 1.53-10.51; P=0.005) higher composite score (for each point increase, odds 1.42; 1.03-1.97; P=0.033). also found independent associations pre-ICH decline presence cortical superficial siderosis, strictly lobar microbleeds, location, but other markers, disease score.CAA (defined markers) symptomatic ICH. This provides evidence that disruption makes an contribution impairment, addition effects due brain injury directly ICH.URL: https://www.clinicaltrials.gov. Unique identifier: NCT02513316.