Ischemic Stroke in Patients With Hypertrophic Cardiomyopathy According to Presence or Absence of Atrial Fibrillation

• DOI: 10.1161/strokeaha.121.034213
• Publication Date: 2021-10-04T17:17:39Z
• Authors: Laurent Fauchier; Arnaud Bisson; Alexandre Bodin; Julien Herbert; Pascal Spiesser; Bertrand Pierre; Nicolas Clementy; Anne Bernard; Dominique Babuty; Gregory Y.H. Lip
• Keywords: Stroke

Patients with hypertrophic cardiomyopathy (HCM) have high risk of ischemic stroke (IS), especially if atrial fibrillation (AF) is present. Improvements in stratification are needed to help identify those patients HCM at higher stroke, whether AF present or not.This French longitudinal cohort study from the database covering hospital care 2010 2019 analyzed adults hospitalized isolated HCM. A logistic regression model was used construct a score, which compared Risk-CVA and CHA2DS2-VASc scores using c-indexes calibration analysis.In 32 206 HCM, 12 498 (38.8%) had AF, 2489 (7.7%) sustained an IS during follow-up. independently associated for death (hazard ratio, 1.129 [95% CI, 1.088-1.172]), cardiovascular 1.254 1.177-1.337]), 1.210 1.111-1.317]), other major events. Independent predictors were older age, heart failure, prior IS, smoking poor nutrition (all P<0.05). For score all 0.65 0.70, good calibration. Among marginal improvement over but less predictive (P=0.001). In without both significantly better prediction (both P<0.0001). Decision curve analysis demonstrated that best clinical usefulness 3 tested scores.Patients prevalence significant presence worse outcomes. simple shows usefulness,