Safety and Efficacy of Remote Ischemic Conditioning in Patients With Intravenous Thrombolysis: The SERIC-IVT Trial
Stroke
Clinical endpoint
DOI:
10.1161/strokeaha.124.048509
Publication Date:
2025-01-08T10:00:47Z
AUTHORS (161)
ABSTRACT
BACKGROUND: Approximately half of the patients with acute ischemic stroke who receive intravenous thrombolysis (IVT) do not achieve an excellent outcome. Remote conditioning (RIC) as a promising neuroprotective treatment may improve clinical outcomes in this population. This study aimed to assess efficacy and safety RIC IVT. METHODS: multicenter, participant-blinded, blinded end point, randomized controlled trial included 558 underwent IVT 18 hospitals from August 2021 May 2023. After IVT, were 1:1 (unilateral upper limb; cuff pressure, 200 mm Hg, twice daily for 7 days) or sham groups (the same procedure; 60 Hg). The primary outcome was functional (modified Rankin Scale score, 0–1) at 90 days after RESULTS: In total, eligible randomized, 11 (2.0%) excluded because they did RIC. Thus, 547 (RIC, n=274; RIC, n=273) modified intention-to-treat analysis, whom 15 lost follow-up 532 (95.3%) completed trial. At days, 62.7% group 56.8% had (unadjusted risk ratio, 1.10 [95% CI, 0.96–1.27]; P =0.169). proportion any adverse events 11.2% 8.1% group, no significant difference ( =0.221). CONCLUSIONS: safe received However, it significantly REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT04980625.
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