Endovascular Treatment in Patients With Acute Ischemic Stroke and Comorbid Cancer: Analysis of the Italian Registry of Endovascular Treatment in Acute Stroke

• DOI: 10.1161/svin.122.000423
• Publication Date: 2022-10-25T12:09:30Z
• Authors: Federica Letteri; Giovanni Pracucci; Valentina Saia; Fabrizio Sallustio; Alfredo Paolo Mas...; Valerio Da Ros; Rossana Tassi; Maurizio Acampa; Sandra Bracco; Alessandro De Vito; Ilaria Casetta; Andrea Saletti; Guido Bigliardi; Stefano Vallone; Marta Iacobucci; Patrizia Nencini; Vanessa Palumbo; Sergio Nappini; Laura Malfatto; Cinzia Finocchi; Lucio Castellan; Simona Sacco; Nicola Giannini; Guido Andrea Lazz...; Roberto Cavallo; Chiara Comelli; Adriana Critelli; Nicola Cavasin; Simona Marcheselli; Nunzio Paolo Nuzzi; Mauro Magoni; Roberto Gasparotti; Paolo Invernizzi; Marco Pavia; Angelica Tinelli; Nicola Burdi; Tiziana Tassinari; Riccardo Padolecchia; Marco Petruzzellis; Luigi Chiumarulo; Maria Valeria Saddi; Giovanni Dui; Monia Russo; Pietro Amistà; Andrea Zini; Salvatore Mangiafico; Danilo Toni
• Keywords: Stroke

Background Acute stroke patients with comorbid cancer (CC) are more preferably addressed endovascular treatment (EVT) than thrombolytic therapy, due to the presumed potential risk of hemorrhagic transformation and systemic bleeding. This study aims evaluate clinical procedural outcomes acute CC receiving EVT. Methods Using Italian Registry Endovascular Treatment in Stroke, we reviewed prospectively collected data treated EVT from 2011 2017. Outcome measures were modified Thrombolysis Cerebral Infarction score, symptomatic intracranial hemorrhage rate, 3‐month Rankin scale. We also compared a control group without (non‐comorbid cancer) matched 2 populations 1:1 propensity score. Results Out 4598 EVT, 165 (3.6%) had CC. Modified 2b‐3 was obtained 73.8% 74.5% non‐comorbid ( P =0.84), whereas rate 8.2% 6.9%, respectively. Three‐month all‐cause mortality 33.3% 18.6% <0.001), after score 35.4% 22.1%, respectively =0.012). In patients, presence metastasis recent diagnosis significantly associated higher =0.018 0.021, respectively). Breast showed significant correlation mild or no disability (odds ratio, 3.32; CI, 1.28–8.67; =0.014) less death cases at 3‐months 0.44; 0.16–1.21; =0.114) other most represented malignancies. Conclusion Although successful recanalization comparable both groups. metastatic active disease seem be poorer functional outcome, breast appears frequent long term.