Connection strength of the macaque connectome augments topological and functional network attributes

• DOI: 10.1162/netn_a_00101
• Publication Date: 2019-06-25T15:45:41Z
• Authors: Siemon C. de Lange; Dirk Jan Ardesch; Martijn P. van de...
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Electronic computers. Computer science; QA75.5-76.95; Research Articles

Mammalian brains constitute complex organized networks of neural projections. On top their binary topological organization, the strength (or weight) these projections can be highly variable across connections and is thus likely additional importance to overall functional organization network. Here we investigated specific distribution pattern connection in macaque connectome. We performed weighted network analysis on cortico-cortical connectivity provided by unique tract-tracing dataset Markov colleagues (2014) observed both analyses a small-world, modular rich club organization. Moreover, showed augmenting architecture identified version enhancing local clustering central infrastructure for global communication integration. Functional consequences this were further examined using Kuramoto model simulating interactions between brain regions that enhances synchronization within modules hubs. Together, our results suggest pathway promotes properties connectome processing