Muscle energy metabolism and nutritional status in patients with chronic obstructive pulmonary disease. A 31P magnetic resonance study.

• DOI: 10.1164/ajrccm.152.2.7633721
• Publication Date: 2013-04-04T21:53:10Z
• Authors: T Kutsuzawa; S Shioya; D Kurita; M Haida; Y Ohta; H Yamabayashi
• Keywords: Adult; Male; 2. Zero hunger; Magnetic Resonance Spectroscopy; Phosphocreatine; Body Weight; Nutritional Status; Phosphorus; Middle Aged; Hand; Nutrition Disorders; Phosphates; 3. Good health; 03 medical and health sciences; Adenosine Triphosphate; 0302 clinical medicine; Case-Control Studies; Humans; Lung Diseases, Obstructive; Energy Metabolism; Muscle, Skeletal; Aged; Hydrogen; Muscle Contraction

We investigated the relationship between nutritional status and muscle energy metabolism during exercise in 18 male patients with chronic obstructive pulmonary disease (COPD) 15 control subjects using 31P nuclear magnetic resonance spectroscopy (31P-MRS). The were further categorized as either a well-nourished (% ideal body weight, % IBW > or = 90) malnourished < state. Muscle was evaluated by determining ratios PCr/(PCr + Pi) (PCr, phosphocreatine; Pi, inorganic phosphate), ATP/(PCr Pi ATP). consisted of repetitive hand grips performed against load. work rate normalized for individual's lean mass dividing forearm fat-free cross-sectional area, which calculated 1H-MRS. values did not correlate any groups COPD patients. Furthermore, subject groups. However, there correlations within consistently lower than subjects. These findings suggest that altered is affected their status.