Infants with Flow Limitation at 4 Weeks

• DOI: 10.1164/rccm.200110-018oc
• Publication Date: 2002-07-27T13:02:33Z
• Authors: Stephen W. Turner; Lyle J. Palmer; Peter J. Rye; Neil A. Gibson; Parveenjeet K. Judge; Sally Young; Louis I. Landau; Peter N. Le Souëf
• Keywords: Wheeze; Expiration; Atopy

Within a longitudinal study of lung function in 243 infants, we identified group 23 individuals with flow limitation tidal expiration. In infancy, flow-limited children have reduced and increased airway responsiveness (AR), at 2 years age they are diagnosed asthma more frequently. We hypothesized that these observations would persist throughout childhood. Data from ages 3 to 11 were analyzed. Only 4 did the wheeze compared other cohort members (odds ratio, 4.25; 95% confidence interval [CI], 1.11 16.2; p = 0.04; n 114). At 6 age, 117 seen. The (n 14) had greater AR (p 0.009) mean FEV(1) (131 ml; CI, 16 246; 0.03) FEF(25-75) (0.28 L/second; 0.05 0.52; 0.02). 183 seen 18) 0.02) trend toward (0.24 -0.02 0.49; 0.08). Atopy parental not group. suggest physiologic abnormality causes early infancy may identify an at-risk group, different asthma, who later life.